銆€銆€2017骞磋嚚搴婂煼(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯稖鍚堢瓎瑭﹁€冭│鏅�(sh铆)闁撳畾浜�8鏈�26鏃ャ€傜偤鏂逛究鑰冪敓寰�(f霉)缈�(x铆)锛岀挵(hu谩n)鐞冪恫(w菐ng)鏍″垎浜�“2017鑷ㄥ簥鍩�(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯€冭│鐢熺墿鍖栧(xu茅)寰�(f霉)缈�(x铆)绛嗚绗竴绔犺泲鐧借唱(zh矛)鐨勫寲瀛�(xu茅)”銆傛洿澶氬収(n猫i)瀹规暚璜�(q菒ng)闂�(gu膩n)娉ㄧ挵(hu谩n)鐞冪恫(w菐ng)鏍¤嚚搴婂煼(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯€冭│闋婚亾锛屾垜鍊戞渻(hu矛)绔獱(ch茅ng)鎻愪緵鏇村鏈夊児(ji脿)鍊肩殑鑰冭│鍕�(d貌ng)鎱�(t脿i)鍙婂京(f霉)缈�(x铆)璩囨枡銆�

銆€銆€鐩搁棞(gu膩n)鎺ㄨ枽锛�2017鑷ㄥ簥鍩�(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯€冭│鐢熺墿鍖栧(xu茅)寰�(f霉)缈�(x铆)绛嗚鍖附

銆€銆€绗竴绔� 铔嬬櫧璩�(zh矛)鐨勫寲瀛�(xu茅)

銆€銆€绗竴绡€(ji茅) 铔嬬櫧璩�(zh矛)鐨勫垎瀛愮祫鎴�

銆€銆€涓€銆佽泲鐧借唱(zh矛)鐨勫厓绱犵祫鎴�

銆€銆€缍�(j墨ng)鍏冪礌鍒嗘瀽锛屼富瑕佹湁 C(50%锝�55%)銆丠(6%锝�7%)銆丱(19%锝�24%)銆丯(13%锝�19%)銆丼(0%锝�4%)銆傛湁浜涜泲鐧借唱(zh矛)閭勫惈寰噺鐨凱銆丗e銆丆u銆乑n銆丮n銆丆o銆丮o銆両绛�銆�

銆€銆€鍚勭ó铔嬬櫧璩�(zh矛)鐨勫惈姘噺寰堟帴杩�锛屽钩鍧囩偤16%銆傚洜姝�锛屽彲浠ョ敤瀹氭爱娉曚締(l谩i)鎺ㄧ畻妯ｅ搧涓泲鐧借唱(zh矛)鐨勫ぇ鑷村惈閲�銆�

銆€銆€姣忓厠妯ｅ搧鍚爱鍏嬫暩(sh霉)×6.25×100=100g妯ｅ搧涓泲鐧借唱(zh矛)鍚噺(g%)

銆€銆€浜屻€佽泲鐧借唱(zh矛)鐨勫熀鏈祫鎴愬柈浣�——姘ㄥ熀閰�

銆€銆€铔嬬櫧璩�(zh矛)鍦ㄩ吀銆佸牽鎴栬泲鐧介叾鐨勪綔鐢ㄤ笅锛屾渶绲傛按瑙ｇ偤娓搁洟姘ㄥ熀閰�(amino acid)锛屽嵆铔嬬櫧璩�(zh矛)绲勬垚鍠珨鎴栨(g貌u)浠跺垎瀛�銆傚瓨鍦ㄤ簬鑷劧鐣屼腑鐨勬皑鍩洪吀鏈�300浣欑ó锛屼絾鍚堟垚铔嬬櫧璩�(zh矛)鐨勬皑鍩洪吀鍍�20绋�(绋辩法纰兼皑鍩洪吀)锛屾渶鍏堢櫦(f膩)鐝�(xi脿n)鐨勬槸澶╅杸鍐皑閰�(1806骞�)锛屾渶鍚庨憭瀹氱殑鏄槆姘ㄩ吀(1938骞�)銆�

銆€銆€(涓€)姘ㄥ熀閰哥殑绲�(ji茅)妲�(g貌u)閫氬紡

銆€銆€绲勬垚铔嬬櫧璩�(zh矛)鐨�20绋皑鍩洪吀鏈夊叡鍚岀殑绲�(ji茅)妲�(g貌u)鐗归粸(di菐n)锛�

銆€銆€1.姘ㄥ熀閫ｆ帴鍦�α- C涓�锛屽爆浜�α-姘ㄥ熀閰�(鑴皑閰哥偤α-浜炴皑鍩洪吀)銆�

銆€銆€2.R鏄伌(c猫)閺堬紝闄ょ敇姘ㄩ吀澶栭兘鍚墜鎬锛屾湁D-鍨嬪拰L-鍨嬪叐绋珛楂旂暟妲�(g貌u)楂斻€傚ぉ鐒惰泲鐧借唱(zh矛)涓殑姘ㄥ熀閰搁兘鏄疞-鍨�銆�

銆€銆€娉ㄦ剰锛氭(g貌u)鍨嬫槸鎸囧垎瀛愪腑鍚勫師瀛愮殑鐗瑰畾绌洪枔鎺掑竷锛屽叾璁婂寲瑕佹眰鍏卞児(ji脿)閸电殑鏂疯鍜岄噸鏂板舰鎴愩€傛棆鍏夋€ф槸鐣版(g貌u)楂旂殑鍏夊(xu茅)娲绘€�锛屾槸浣垮亸鎸厜骞抽潰鍚戝乏鎴栧悜鍙虫棆杞�(zhu菐n)鐨勬€ц唱(zh矛)锛�(-)琛ㄧず宸︽棆锛�(+)琛ㄧず鍙虫棆銆傛(g貌u)鍨嬭垏鏃嬪厜鎬ф矑(m茅i)鏈夌洿鎺ュ皪(du矛)鎳�(y墨ng)闂�(gu膩n)绯�銆�

銆€銆€(浜�)姘ㄥ熀閰哥殑鍒嗛

銆€銆€1.鎸塕鍩虹殑鍖栧(xu茅)绲�(ji茅)妲�(g貌u)鍒嗙偤鑴傝偑鏃�銆佽姵棣欐棌銆侀洔鐠�(hu谩n)銆侀洔鐠�(hu谩n)浜炴皑鍩洪吀鍥涢銆�

銆€銆€2.鎸塕鍩虹殑妤垫€у拰鍦ㄤ腑鎬ф憾娑茬殑瑙ｉ洟鐙€鎱�(t脿i)鍒嗙偤闈炴サ鎬ф皑鍩洪吀銆佹サ鎬т笉甯堕浕鑽�銆佹サ鎬у付璨�(f霉)闆昏嵎鎴栧付姝ｉ浕鑽风殑鍥涢銆�

銆€銆€甯舵湁闈炴サ鎬(鐑村熀銆佺敳纭熀銆佸惒鍝氱挵(hu谩n)绛夛紝鍏�9绋�)锛氱敇(Gly)銆佷笝(Ala)銆佺簣(Val)銆佷寒(Leu)銆佺暟浜�(Ile)銆佽嫰涓�(Phe)銆佺敳纭�(Met)銆佽劘(Pro)銆佽壊(Trp)

銆€銆€甯舵湁涓嶅彲瑙ｉ洟鐨勬サ鎬(缇ュ熀銆佸钒鍩�銆侀叞鑳哄熀绛�锛屽叡6绋�)锛氱挡(Ser)銆佽槆(Thr)銆佸ぉ鑳�(Asn)銆佽胺鑳�(Gln)銆侀叒(Tyr)銆佸崐(Cys)

銆€銆€甯舵湁鍙В闆㈢殑妤垫€鍩�(鍏�5绋�)锛氬ぉ(Asp)銆佽胺(Glu)銆佽炒(Lys)銆佺簿(Arg)銆佺祫(His)锛屽墠鍏╁€�(g猫)鐐洪吀鎬ф皑鍩洪吀锛屽悗涓夊€�(g猫)鏄牽鎬ф皑鍩洪吀銆�

銆€銆€铔嬬櫧璩�(zh矛)鍒嗗瓙涓殑鑳辨皑閰告槸鍏╁€�(g猫)鍗婅儽姘ㄩ吀鑴矮鍚庝互浜岀～閸电祼(ji茅)鍚堣€屾垚锛岃啝鍘熻泲鐧戒腑鐨勭茎鑴皑閰搞€佺茎璩存皑閰�锛屽嚌琛€閰跺師涓殑缇у熀璋锋皑閰告槸铔嬬櫧璩�(zh矛)鍔犲伐淇＞鑰屾垚銆�

銆€銆€(涓�)姘ㄥ熀閰哥殑閲嶈鐞嗗寲鎬ц唱(zh矛)

銆€銆€1.涓€鑸墿鐞嗘€ц唱(zh矛)

銆€銆€α-姘ㄥ熀閰哥偤鐒�(w煤)鑹叉櫠楂�锛岀啍榛�(di菐n)涓€鑸湪200 oC浠ヤ笂銆傚悇绋皑鍩洪吀鍦ㄦ按涓殑婧惰В搴﹀樊鍒ュ緢澶�(閰皑閰镐笉婧朵簬姘�)銆備竴鑸憾瑙ｄ簬绋€閰告垨绋€鍫�锛屼絾涓嶈兘婧惰В浜庢湁姗�(j墨)婧跺姂锛岄€氬父閰掔簿鑳芥妸姘ㄥ熀閰稿緸鍏舵憾娑蹭腑娌夋穩鏋愬嚭銆�

銆€銆€鑺抽鏃忔皑鍩洪吀(Tyr銆乀rp銆丳he)鏈夊叡杌涢洐閸�锛屽湪杩戠传澶栧崁(q奴)鏈夊厜鍚告敹鑳藉姏锛孴yr銆乀rp鐨勫惛鏀跺嘲鍦�280nm锛孭he鍦�265 nm銆傜敱浜庡ぇ澶氭暩(sh霉)铔嬬櫧璩�(zh矛)鍚玊yr銆乀rp娈樺熀锛屾墍浠ユ脯(c猫)瀹氳泲鐧借唱(zh矛)婧舵恫280nm鐨勫厜鍚告敹鍊�锛屾槸鍒嗘瀽婧舵恫涓泲鐧借唱(zh矛)鍚噺鐨勫揩閫熺啊(ji菐n)渚跨殑鏂规硶銆�

銆€銆€2.鍏╂€цВ闆㈠拰绛夐浕榛�(di菐n)(isoelectric point, pI)

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銆€銆€鑻�1鍊�(g猫)姘ㄥ熀閰告湁3鍊�(g猫)鍙В闆㈠熀鍦�(tu谩n)锛屽(xi臎)鍑哄畠鍊戦浕闆㈠紡鍚庡彇鍏兼€ч洟瀛愬叐閭婄殑pK鍊肩殑骞冲潎鍊�锛屽嵆鐐烘姘ㄥ熀閰哥殑绛夐浕榛�(di菐n)(閰告€ф皑鍩洪吀鐨勭瓑闆婚粸(di菐n)鍙栧叐缇у熀鐨刾K鍊肩殑骞冲潎鍊�锛屽牽鎬ф皑鍩洪吀鐨勭瓑闆婚粸(di菐n)鍙栧叐姘ㄥ熀鐨刾K鍊肩殑骞冲潎鍊�)銆�

銆€銆€3.姘ㄥ熀閰哥殑鍖栧(xu茅)鍙嶆噳(y墨ng)

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銆€銆€(2)鑸�2锛�4-浜岀鍩烘盁鑻�(DNFB)鐨勫弽鎳�(y墨ng)

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銆€銆€涓�銆佽偨(peptide)

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銆€銆€2.α-铻烘棆(α-helix)

銆€銆€α-铻烘棆鏄偨閸靛钩闈㈤€氶亷(gu貌)α-纰冲師瀛愮殑鐩稿皪(du矛)鏃嬭綁(zhu菐n)褰㈡垚鐨勪竴绋穵瀵嗚灪鏃嬬洡(p谩n)绻�锛屾槸鏈夊懆鏈熺殑涓€绋富閺堟(g貌u)璞°€傚叾鐗归粸(di菐n)鏄細

銆€?銆�?铻烘棆姣忚綁(zhu菐n)涓€鍦堜笂鍗�3.6鍊�(g猫)姘ㄥ熀閰告畼鍩�锛岃灪璺濈磩0.54nm(姣忓€�(g猫)娈樺熀涓婂崌0.15nm锛屾棆杞�(zhu菐n)100O)銆�

銆€?銆�?鐩搁劙鐨勮灪鍦堜箣闁撳舰鎴愰張鍏�(n猫i)姘嵉锛屾矮閸电殑鍙栧悜骞句箮鑸囦腑蹇冭桓骞宠銆傚吀鍨�α-铻烘棆涓€灏�(du矛)姘嵉O鑸嘚涔嬮枔鍏辨湁13鍊�(g猫)鍘熷瓙(3.613)锛屽墠鍚庨枔闅�3鍊�(g猫)娈樺熀銆�

銆€?銆佸嫄鑿悶娣栧懄铓猑澶ч儴鍒嗘槸鍙虫墜铻烘棆锛屾畼鍩哄伌(c猫)閺堜几鍚戝鍋�(c猫)銆俁鍩哄湗(tu谩n)鐨勫ぇ灏�銆佽嵎闆荤媭鎱�(t脿i)鍙婂舰鐙€鍧囧皪(du矛)α-铻烘棆鐨勫舰鎴愬強绌�(w臎n)瀹氭湁褰遍熆銆�

銆€銆€3.β-鎶樼枈(β-pleated sheet)

銆€銆€β-鎶樼枈鏄竴绋偨閺堢浉鐣�(d膩ng)浼稿睍鐨勫懆鏈熸€х祼(ji茅)妲�(g貌u)銆�

銆€?銆�?鐩搁劙鑲介嵉骞抽潰闁撴姌鐤婃垚110O瑙�锛屽憟閶搁綊鐙€銆�

銆€銆€鈶� 鍏╁€�(g猫)浠ヤ笂鍏�β-鎶樼枈鐨勮偨閺堟垨鍚屼竴鑲介張鍏�(n猫i)涓嶅悓鑲芥鐩镐簰骞宠鎺掑垪锛屽舰鎴�β-鎶樼枈鐗囧堡锛屽叾绌�(w臎n)瀹氬洜绱犳槸鑲介張闁撶殑姘嵉銆�

銆€銆€鈶� 閫嗗悜骞宠鐨勭墖灞ょ祼(ji茅)妲�(g貌u)姣旈爢鍚戝钩琛岀殑绌�(w臎n)瀹�銆�

銆€銆€α-铻烘棆鍜�β-鎶樼枈鏄泲鐧借唱(zh矛)浜岀礆(j铆)绲�(ji茅)妲�(g貌u)鐨勪富瑕佸舰寮�銆傛瘺鐧�(f膩)涓殑α-瑙掕泲鐧藉拰锠剁挡涓殑绲插績铔嬬櫧鏄叾鍏稿瀷锛屽湪瑷卞鐞冭泲鐧戒腑涔熷瓨鍦紝浣嗘墍鍗犳瘮渚嬩笉涓€妯�銆�

銆€銆€鑶犲師铔嬬櫧涓瓨鍦ㄧ殑铻烘棆绲�(ji茅)妲�(g貌u)涓嶅悓浜庝竴鑸殑α-铻烘棆锛屾槸鐢�3姊濆叿鏈夊乏鎵嬭灪鏃嬬殑閺堢浉浜掔簭绻炲舰鎴愬彸鎵嬭秴铻烘棆鍒嗗瓙銆傞張闁撴矮閸典互鍙婅灪鏃嬪拰瓒呰灪鏃嬬殑鍙嶅悜鐩�(p谩n)绻炵董鎸佸叾绌�(w臎n)瀹氭€�銆�

銆€銆€4.β-杞�(zhu菐n)瑙�(β-turn)

銆€銆€鐐轰簡绶婄穵鎶樼枈鎴愮悆铔嬬櫧鐨勭穵瀵嗗舰鐙€锛屽鑲介張180O鍥炴姌鎴愮櫦(f膩)澶炬垨β-杞�(zhu菐n)瑙�銆傚叾铏曠敱4鍊�(g猫)閫ｇ簩(x霉)鐨勬皑鍩洪吀娈樺熀妲�(g貌u)鎴�锛屽父鏈塆ly鍜孭ro瀛樺湪锛岀┅(w臎n)瀹�β-杞�(zhu菐n)瑙掔殑浣滅敤鍔涙槸绗竴鍊�(g猫)姘ㄥ熀閰告畼鍩虹景鍩烘哀(O)鑸囩鍥涘€�(g猫)姘ㄥ熀閰告畼鍩虹殑姘ㄥ熀姘�(H)涔嬮枔褰㈡垚鐨勬矮閸�銆�β-杞�(zhu菐n)瑙掑父瑕�(ji脿n)浜庨€ｆ帴鍙嶅钩琛�β-鎶樼枈鐗囩殑绔牠銆�

銆€銆€鐠�(hu谩n)鐞冪恫(w菐ng)鏍″弸鎯呮彁渚涳細鑷ㄥ簥鍩�(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯€冭│璜栧锛岄毃鏅�(sh铆)鑸囧唬澶ц€冪敓鏈嬪弸鍊戜竴璧蜂氦娴�!

绶ㄨ集鎺ㄨ枽锛�

2017骞磋嚚搴婂姪鐞嗛啱(y墨)甯€冭│鐢ㄦ浉(sh奴)鍏�(n猫i)瀹硅畩鍖栧皪(du矛)姣�—鐢熺墿鍖栧(xu茅)

2017骞磋嚚搴婂姪鐞嗛啱(y墨)甯硣鏍煎ぇ缍�—鐢熺墿鍖栧(xu茅)

鑷ㄥ簥鍔╃悊閱�(y墨)甯€冭│鐢熺墿鍖栧(xu茅)姝峰勾楂橀牷鑰冮粸(di菐n)鍖附

鑷ㄥ簥鍩�(zh铆)妤�(y猫)(鍔╃悊)閱�(y墨)甯€冭│鐢熺墿鍖栧(xu茅)閲嶈鐭ヨ瓨(sh铆)榛�(di菐n)姝哥磵|鐢熺墿鍖栧(xu茅)蹇呰儗鐭ヨ瓨(sh铆)榛�(di菐n)

鑷ㄥ簥鍩�(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯€冭│鐢熺墿鍖栧(xu茅)姝峰勾閲嶈鐭ヨ瓨(sh铆)榛�(di菐n)姝哥磵

銆€銆€2017骞磋嚚搴婂煼(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯稖鍚堢瓎瑭﹁€冭│鏅�(sh铆)闁撳畾浜�8鏈�26鏃�銆傜偤鏂逛究鑰冪敓寰�(f霉)缈�(x铆)锛岀挵(hu谩n)鐞冪恫(w菐ng)鏍″垎浜�“2017鑷ㄥ簥鍩�(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯€冭│鐢熺墿鍖栧(xu茅)寰�(f霉)缈�(x铆)绛嗚绗竴绔犺泲鐧借唱(zh矛)鐨勫寲瀛�(xu茅)”銆傛洿澶氬収(n猫i)瀹规暚璜�(q菒ng)闂�(gu膩n)娉ㄧ挵(hu谩n)鐞冪恫(w菐ng)鏍¤嚚搴婂煼(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯€冭│闋婚亾锛屾垜鍊戞渻(hu矛)绔獱(ch茅ng)鎻愪緵鏇村鏈夊児(ji脿)鍊肩殑鑰冭│鍕�(d貌ng)鎱�(t脿i)鍙婂京(f霉)缈�(x铆)璩囨枡銆�

銆€銆€鐩搁棞(gu膩n)鎺ㄨ枽锛�2017鑷ㄥ簥鍩�(zh铆)妤�(y猫)鍔╃悊閱�(y墨)甯€冭│鐢熺墿鍖栧(xu茅)寰�(f霉)缈�(x铆)绛嗚鍖附

銆€銆€5.鐒�(w煤)瑕�(gu墨)鍗锋洸(random coil)

銆€銆€澶氳偨閺堢殑涓婚張鍛堢従(xi脿n)鐒�(w煤)纰哄畾瑕�(gu墨)寰嬬殑鍗锋洸銆傚吀鍨嬬悆铔嬬櫧澶х磩涓€鍗婂鑲介張?zh菙n)娌丂妯ｇ殑妲�(g貌u)璞�銆�

銆€銆€6.瓒呬簩绱�(j铆)绲�(ji茅)妲�(g貌u)鍜岀祼(ji茅)妲�(g貌u)鍩�

銆€銆€瓒呬簩绱�(j铆)绲�(ji茅)妲�(g貌u)鍜岀祼(ji茅)妲�(g貌u)鍩熸槸铔嬬櫧璩�(zh矛)浜岀礆(j铆)鑷充笁绱�(j铆)绲�(ji茅)妲�(g貌u)灞ゆ鐨勪竴绋亷(gu貌)娓℃厠(t脿i)妲�(g貌u)璞�銆�

銆€銆€瓒呬簩绱�(j铆)绲�(ji茅)妲�(g貌u)鎸囪泲鐧借唱(zh矛)涓叐鍊�(g猫)鎴栦笁鍊�(g猫)鍏锋湁浜岀礆(j铆)绲�(ji茅)妲�(g貌u)鐨勮偨娈靛湪绌洪枔涓婄浉浜掓帴杩�锛屽舰鎴愪竴鐗规畩鐨勭祫鍚堥珨锛屽張绋辩偤妯￠珨(motif)銆傞€氬父鏈�αα锛�ββ锛�βαβ绛�锛屼緥濡傞垼绲�(ji茅)鍚堣泲鐧借唱(zh矛)涓殑铻烘棆-鐠�(hu谩n)-铻烘棆妯″簭鍙婇媴鎸囩祼(ji茅)妲�(g貌u)銆�

銆€銆€绲�(ji茅)妲�(g貌u)鍩熸槸鐞冪媭铔嬬櫧璩�(zh矛)鐨勬姌鐤婂柈浣�锛屾槸鍦ㄨ秴浜岀礆(j铆)绲�(ji茅)妲�(g貌u)鍩虹(ch菙)涓婇€�(j矛n)涓€姝ョ篂鏇叉姌鐤婃湁鐛�(d煤)鐗规(g貌u)璞″拰閮ㄥ垎鐢熺墿瀛�(xu茅)鍔熻兘鐨勭祼(ji茅)妲�(g貌u)銆傚皪(du矛)浜庤純灏忕殑铔嬬櫧璩�(zh矛)鍒嗗瓙鎴栦簽鍩�锛岀祼(ji茅)妲�(g貌u)鍩熷拰涓夌礆(j铆)绲�(ji茅)妲�(g貌u)鏄竴鍊�(g猫)鎰忔€�锛屽嵆閫欎簺铔嬬櫧璩�(zh矛)鏄柈绲�(ji茅)妲�(g貌u)鍩熺殑;灏�(du矛)浜庤純澶х殑铔嬬櫧璩�(zh矛)鍒嗗瓙鎴栦簽鍩�锛屽鑲介張寰€寰€鐢卞叐鍊�(g猫)鎴栧叐鍊�(g猫)浠ヤ笂鐨勭浉灏�(du矛)鐛�(d煤)绔嬬殑绲�(ji茅)妲�(g貌u)鍩熺窢鍚堟垚涓夌礆(j铆)绲�(ji茅)妲�(g貌u)銆�

銆€銆€涓�銆佽泲鐧借唱(zh矛)鐨勪笁绱�(j铆)绲�(ji茅)妲�(g貌u)(tertiary structure)

銆€銆€鎸囦竴姊濆鑲介張涓墍鏈夊師瀛愮殑鏁撮珨鎺掑竷锛屽寘鎷富閺堝拰鍋�(c猫)閺�銆傜董绯讳笁绱�(j铆)绲�(ji茅)妲�(g貌u)鐨勪綔鐢ㄥ姏涓昏鏄绱�(j铆)閸�(鐤忔按鐩镐簰浣滅敤銆侀潨闆诲姏銆佹矮閸电瓑)銆傚湪搴忓垪涓浉闅旇純閬�(yu菐n)鐨勬皑鍩洪吀鐤忔按鍋�(c猫)閺堢浉浜掗潬杩�锛屽舰鎴�“娲炵┐”鎴�“鍙ｈ”鐙€绲�(ji茅)妲�(g貌u)锛岀祼(ji茅)鍚堣泲鐧借唱(zh矛)鐨勮紨鍩哄線寰€閼插祵鍏跺収(n猫i)锛屽舰鎴愬姛鑳芥椿鎬ч儴浣�锛岃€岃Κ姘村熀鍦�(tu谩n)鍓囧湪澶�锛岄€欎篃鏄悆鐙€铔嬬櫧璩�(zh矛)鏄撴憾浜庢按鐨勫師鍥犮€�1963骞碖endrew绛夊緸榀ㄨ倢绱呰泲鐧界殑X灏勭窔琛嶅皠鍦栬瓬娓�(c猫)瀹氬畠鐨勪笁绱�(j铆)绲�(ji茅)妲�(g貌u)(153鍊�(g猫)姘ㄥ熀閰告畼鍩哄拰涓€鍊�(g猫)琛€绱呯礌杓斿熀锛岀浉灏�(du矛)鍒嗗瓙璩�(zh矛)閲忕偤17800)銆傜敱A→H 8娈�α-铻烘棆鐩�(p谩n)绻炴姌鐤婃垚鐞冪媭锛屾皑鍩洪吀娈樺熀涓婄殑鐤忔按鍋�(c猫)閺堝ぇ閮藉湪鍒嗗瓙鍏�(n猫i)閮ㄥ舰鎴愪竴鍊�(g猫)琚嬪舰绌虹┐锛岃绱呯礌灞呬簬鍏朵腑锛屽瘜鏈夋サ鎬у強闆昏嵎鐨勫墖鍦ㄥ垎瀛愯〃闈㈠舰鎴愯Κ姘寸殑鐞冪媭铔嬬櫧銆�

銆€銆€鍥�銆佽泲鐧借唱(zh矛)鐨勫洓绱�(j铆)绲�(ji茅)妲�(g貌u) (quaternary structure)

銆€銆€鏈変簺铔嬬櫧璩�(zh矛)鐨勫垎瀛愰噺寰堝ぇ锛岀敱2姊濇垨2姊濅互涓婂叿鏈夌崹(d煤)绔嬩笁绱�(j铆)绲�(ji茅)妲�(g貌u)鐨勫鑲介張閫氶亷(gu貌)闈炲叡鍍�(ji脿)閸电浉浜掔祼(ji茅)鍚堣€屾垚锛岀ū鐐鸿泲鐧借唱(zh矛)鐨勫洓绱�(j铆)绲�(ji茅)妲�(g貌u)銆傛(g貌u)鎴愬洓绱�(j铆)绲�(ji茅)妲�(g貌u)鐨勬瘡姊濆鑲介張绋辩偤浜炲熀 (subunit)锛屼簽鍩哄柈鐛�(d煤)瀛樺湪鏅�(sh铆)涓€鑸矑(m茅i)鏈夌敓鐗╁(xu茅)鍔熻兘锛屾(g貌u)鎴愬洓绱�(j铆)绲�(ji茅)妲�(g貌u)鐨勫咕鍊�(g猫)浜炲熀鍙互鐩稿悓鎴栦笉鍚�銆傚琛€绱呰泲鐧�(hemoglobin,Hb) 鏄敱鍏╁€�(g猫)α-浜炲熀鍜屽叐鍊�(g猫)β-浜炲熀褰㈡垚鐨勫洓鑱氶珨(α2β2)銆�

銆€銆€浜�銆佽泲鐧借唱(zh矛)鍒嗗瓙涓殑鍖栧(xu茅)閸�

銆€銆€铔嬬櫧璩�(zh矛)鐨勪竴绱�(j铆)绲�(ji茅)妲�(g貌u)鏄敱鍏卞児(ji脿)閸靛舰鎴愮殑锛屽鑲介嵉鍜屼簩纭嵉銆傝€岀董鎸佺┖闁撴(g貌u)璞＄┅(w臎n)瀹氱殑鏄潪鍏卞児(ji脿)鐨勬绱�(j铆)閸�銆傚姘嵉銆侀菇閸�銆佺枏姘撮嵉銆佽寖寰疯彲寮曞姏绛�銆�

銆€銆€绗笁绡€(ji茅) 铔嬬櫧璩�(zh矛)绲�(ji茅)妲�(g貌u)鑸囧姛鑳界殑闂�(gu膩n)绯�

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